The Meadows/US-29 neighborhood is a 304 acre area located in the northern sector of the city. The neighborhood is outlined by the Albemarle County line, Barracks Road, Route 250 and Brandywine Drive. This portion of the city was annexed from the county in 1963. The residential and commercial developments in this area split the neighborhood into two distinct areas with a wooded strip of land serving as a separation. Seminole Square Shopping Center, located off Route 29 and Hydraulic Road, serves as one of the city's main commercial areas. This site was originally the Peyton Farm. The farm was sold and rezoned for the potential placement of Fashion Square Mall. When the mall did not locate in the city, the property was developed as a shopping center. Its buildings form a horseshoe shape with parking in the center for the various businesses in the shopping center. Additional businesses buffer the parking area from Route 29. The center features national chains including Office Depot and Giant Foods as well as locally owned businesses.

The intersection of Route 29 and Hydraulic Road is a significant feature in this area of the city. Route 29 is a major north-south arterial for Central Virginia. It was constructed in the mid 1970's and traffic volume on the road has increased each year since its construction. Charlottesville is the only major area on Route 29 which has not constructed a Bypass so local and through traffic are routed into the city. The Hydraulic intersection takes a significant number of individuals to and from the heart of the city from Albemarle County, Green County and other areas north of the city.

The Meadows neighborhood, located north of this intersection, is primarily a residential mix of single family and multi-family dwellings originally developed in Albemarle County. Professional offices are located on the Hydraulic Road side of the neighborhood and commercial establishments separate the residential areas from US-29 on the northern side of the roadway. Angus Road is the main throughway to reach the Meadows neighborhood. Meadows Presbyterian Church serves as the center of the neighborhood and is used as a meeting place for the community. This neighborhood does not have a school therefore the children must travel to Greenbrier Elementary. The neighborhood maintains a residential character while being surrounded by dense commercial use. Future development of the county adjacent to this neighborhood has the potential to significantly impact the area.